The Rosemary Berkel and Harry L. Crisp II Southeast Missouri Regional Museum is located in the Cultural Arts Center at Southeast Missouri State University's River Campus. Southeast Missouri is a geological, cultural and transportation crossroads. Archaeologically, the museum has several collections of Native American artifacts, including many Mississippian ceramics from the Beckwith Collection, which contains one of the largest collections of Native American artifacts in North America.
In the Crossroads Theatre, visitors can view a 17-minute video which introduces the region's rich natural and human history. In the Crossroads Gallery, exhibits and kiosks highlight the history of southeast Missouri. Exhibitions in the museum's 1,900-square-foot art gallery feature works by local, regional, national and international artists. The museum also offers a number of special activities, including educational classes and family fun days.