Geographically, Clarksville, Missouri lies halfway between Canada and the Gulf of Mexico, on Highway 79 about 70 miles north of St. Louis and 50 miles south of Hannibal, Missouri. Highway 79, which is part of the Great River Road and designated as a National Scenic Byway, is considered one of the most scenic highways running alongside the Mississippi River.
Clarksville overlooks U.S. Lock and Dam 24 and provides visitors a close vantage point to view river boat and barge traffic on the river. This area on the Mississippi River hosts one of the largest over-wintering populations of migrating bald eagles in the United States and has been recently deemed an "Important Bird Area" by the National Audubon Society. Downtown Clarksville rests at the foot of Lookout Point/Sky Lift Hill, the top of which affords an 800 square mile view of the river and valley and is one of the highest points on the Mississippi River. Clarence Cannon National Wildlife Refuge, Clarence Cannon Dam and Mark Twain Lake are located close by.
This quaint river town is also home to many artisans, antique dealers, furniture makers and specialty craftsmen. There is much to see and do here. Clarksville even has its own 18-hole Eagles Bluff Golf Course. The downtown area is on the National Register of Historic Places and there are many fine historical homes and buildings in town.
We hope you will come and visit Clarksville to enjoy its scenic beauty, wildlife, artisans, antiques and history. Unhurried... Unspoiled... Uncommon...